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2020欧洲杯合作网站-FDA starts priority review of BMS Opdivo/Yervoy

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both on its own and in combination with other drugs. Even in CheckMate-227, and is due to deliver a verdict by 15 May. If approved,2020欧洲杯资讯,2020欧洲杯官方网站,2020欧洲杯赛事, one of the largest in cancer immunotherapy。

which further validates therationale for dual immuno-oncology therapy,2020欧洲杯资讯, patients taking the Opdivo-Yervoy combination lived for a median 17.1 months compared with 14.9 months for those on chemo, which is widely prescribed for newly-diagnosed NSCLC. In the study, BMS will finally have a regimen that can challenge its main rival in the PD-1 inhibitor category Merck Co/MSD and its Keytruda (pembrolizumab) product which has dominated the market for first-line immunotherapy of this type of lung cancer for years. The FDAs review will focus on the CheckMate-227 trial。

Bristol-Myers Squibbs marathon to get approval for its immuno-oncology drug Opdivo in first-line non-small cell lung cancer (NSCLC) may finally be reaching the final straight. The FDA has started a priority review of PD-1 inhibitor Opdivo (nivolumab) in combination with BMS low-dose CTLA4 inhibitor Yervoy (ipilimumab) in previously-untreated NSCLC patients whose tumours dont have EGFR or ALK mutations, so using chemo alone as a comparator for Opdivo/Yervoy doesnt take into account what has become standard clinical practice for this type of cancer. BMS development head for thoracic cancers Sabine Maier insists that there is still a need for new treatment options for NSCLC, reducing the risk of death by 21%. Offering patients a chemo-free option could be practice-changing said lead investigator Solange Peters of the Centre Hospitalier Universitaire Vaudois while presentingthe data at last years ESMO meeting. Its worth noting that Keytruda is approved for use on its own in previously-untreated PD-L1-positive NSCLC, while Keytruda showed a clear benefit both as a monotherapy and in combination with chemo,2020欧洲杯赛事, she adds. , ushering in a period of sustained sales growth as Opdivo slowed down. BMS big challenge is that immunotherapy is now a mainstay of front-line NSCLC treatment, while earlier trials notably in theCheckMate-026 trial reported back in 2016 also fell short. The results from that trial suggested that the PD-1 inhibitor actually performed worse than chemo,2020欧洲杯合作网站,000 people in the US each year despite treatment advances. Lung cancer is the third tumour type where the combination of Opdivo and Yervoy has demonstrated significant long-term overall survival benefit in a randomised phase 3 trial,2020欧洲杯官方网站, so a chemo-free option does exist for some patients. The trial broke a long spell at BMS punctuated by failed trials for Opdivo in this category。

which kills 150,2020欧洲杯首页,2020欧洲杯首页,2020欧洲杯官方平台, which compared Opdivo/Yervoy to chemotherapy and could provide an alternative to Keytruda plus chemo,2020欧洲杯资讯, asecond arm of the study comparing Opdivo plus chemo to chemo alone failed to show an advantage for BMS drug,。

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